2006 Pilot Pen Tennis – Women's singles

Lindsay Davenport was the defending champion, but was forced to retire in the final due to a right shoulder strain.

Justine Henin-Hardenne won the title, leading in the final 6–0, 1–0 until Davenport retired. It was the 5th title of the year for Henin-Hardenne and the 28th of her career.

Seeds
The first four seeds received a bye into the second round. • # 🇫🇷 Amélie Mauresmo (quarterfinals)

• # 🇧🇪 Justine Henin-Hardenne (champion)

• # 🇷🇺 Elena Dementieva (quarterfinals)

• # 🇷🇺 Nadia Petrova (second round)

• # 🇷🇺 Svetlana Kuznetsova (semifinals)

• # Patty Schnyder (first round)

• # 🇺🇸 Lindsay Davenport (final, retired due to a right shoulder strain)

• # 🇷🇺 Anastasia Myskina (first round)