2006 Prairie View A&M Panthers football team

The 2006 Prairie View A&M Panthers football team represented Prairie View A&M University as a member of the Southwestern Athletic Conference (SWAC) during the 2006 NCAA Division I FCS football season. Led by third-year head coach Henry Frazier III, the Panthers compiled an overall record of 3–7, with a mark of 2–7 in conference play, and finished fifth in the SWAC West Division.