2006 SAP Open – Singles

Andy Roddick was the defending champion, but lost in the semifinals to eventual champion Andy Murray.

Murray defeated Lleyton Hewitt 2–6, 6–1, 7–6(7–3), to become 2006 SAP Open Champion, and claim his first ever ATP Tour title.

Seeds
• # 🇺🇸 Andy Roddick (semifinals)

• # 🇺🇸 Andre Agassi (withdrew)

• # 🇦🇺 Lleyton Hewitt (final)

• # 🇪🇸 Tommy Robredo (first round)

• # 🇺🇸 James Blake (first round)

• # Victor Hănescu (withdrew)

• # 🇷🇺 Dmitry Tursunov (second round)

• # Ivo Karlović (first round)