2006 Sioux Falls Cougars football team

The 2006 Sioux Falls Cougars football team represented the University of Sioux Falls in the 2006 NAIA football season. The Cougars won the 2006 NAIA Football National Championship with a 23–19 victory over the top-ranked St. Francis Cougars. The team also won the Great Plains Athletic Conference championship with a perfect 10–0 record. This was the school's second NAIA Championship (1996). The team was coached by Kalen DeBoer.