2006 St. Petersburg Open – Singles

Thomas Johansson was the defending champion.

Mario Ančić won the title, beating Johansson 7–5, 7–6(7–2) in the final.

Seeds
• # 🇷🇺 Nikolay Davydenko (second round, retired because of a foot injury)

• # 🇪🇸 Tommy Robredo (first round)

• # Mario Ančić (champion)

• # 🇩🇪 Tommy Haas (second round)

• # 🇫🇮 Jarkko Nieminen (second round, retired because of a left foot injury)

• # 🇷🇺 Dmitry Tursunov (first round)

• # 🇷🇺 Mikhail Youzhny (second round, withdrew because of an ankle injury)

• # 🇦🇹 Jürgen Melzer (first round)