2006 US Open – Girls' singles

The girls' singles tournament of the 2006 US Open was won by Anastasia Pavlyuchenkova, who beat Tamira Paszek in the final by 3–6, 6–4, 7–5.

Victoria Azarenka was the reigning champion, but she did not defend her title in the juniors this year, having already been elevated to the seniors.

Seeds
• # 🇷🇺 Anastasia Pavlyuchenkova (champion)

• # Caroline Wozniacki (first round)

• # 🇯🇵 Ayumi Morita (third round)

• # Mihaela Buzărnescu (third round)

• # 🇺🇦 Khrystyna Antoniichuk (first round)

• # 🇺🇸 Julia Cohen (third round)

• # 🇸🇰 Dominika Cibulková (second round)

• # Sorana Cîrstea (third round)

• # 🇧🇾 Ksenia Milevskaya (second round)

• # Ioana Raluca Olaru (Quarterfinal)

• # 🇦🇹 Tamira Paszek (finalist)

• # Alexandra Dulgheru (first round)

• # 🇨🇦 Sharon Fichman (Quarterfinal)

• # 🇵🇱 Urszula Radwańska (second round)

• # 🇺🇸 Mary Gambale (first round)

• # 🇧🇷 Teliana Pereira (first round)