2006 West Texas A&M Buffaloes football team

The 2006 West Texas A&M Buffaloes football team represented West Texas A&M University during the 2006 NCAA Division II football season as a member of the Lone Star Conference (LSC). The Buffaloes were led by second-year head coach Don Carthel and played their home games at Kimbrough Memorial Stadium in Canyon, Texas.

For a second-straight season, the Buffaloes won both the LSC South Division and the Lone Star Conference. The team received a bid to the Division II playoffs, losing to in the second round.

Coaching changes
Defensive coordinator Mike Salinas took a position with the Sam Houston Bearkats after just one season with the Buffaloes. Colby Carthel, son of head coach Don Carthel, was named the Buffaloes' new defensive coordinator.