2006 Western & Southern Financial Group Women's Open – Singles

Patty Schnyder was the defending champion, but lost in semifinals to Katarina Srebotnik

Vera Zvonareva won the title, defeating Srebotnik 6–2, 6–4 in the final. It was the 2nd title of the year and the 5th on her career.

Seeds
• # Patty Schnyder (semifinals)

• # 🇷🇺 Anastasia Myskina (first round)

• # 🇸🇰 Daniela Hantuchová (withdrew due to a right foot injury)

• # Katarina Srebotnik (final)

• # Jelena Janković (quarterfinals)

• # 🇫🇷 Marion Bartoli (quarterfinals)

• # 🇫🇷 Tatiana Golovin (first round)

• # 🇦🇷 Gisela Dulko (second round)

• # 🇮🇳 Sania Mirza (quarterfinals)