2006 in São Tomé and Príncipe

The following lists events that happened during 2006 in the Democratic Republic of São Tomé and Príncipe.

Incumbents

 * President: Fradique de Menezes
 * Prime Minister: Maria do Carmo Silveira (until 21 April), Tomé Vera Cruz (from 21 April)

Events

 * Parque Natural Obô de São Tomé and Parque Natural Obô do Príncipe created
 * 25 March: the São Toméan legislative election took place
 * April: the XI Constitutional Government of São Tomé and Príncipe began
 * 18 May - Francisco da Silva succeeded Dionísio Tomé Dias as President of the National Assembly
 * 20 June: João Paulo Cassandra becomes President of the Regional Government of Príncipe
 * 30 July: the São Toméan presidential election took place
 * 5 October: José Cassandra becomes President of the Regional Government of Príncipe