2007 Indianapolis Tennis Championships – Singles

James Blake was the defending champion, but lost in the quarterfinals to Sam Querrey.

Third-seeded Dmitry Tursunov won in the final 6–4, 7–5, against Frank Dancevic.

Seeds
• # 🇺🇸 Andy Roddick (semifinals)

• # 🇺🇸 James Blake (quarterfinals)

• # 🇷🇺 Dmitry Tursunov (champion)

• # 🇺🇸 Mardy Fish (second round, retired due to a left knee injury)

• # Ivo Karlović (second round)

• # 🇰🇷 Hyung-taik Lee (quarterfinals)

• # 🇺🇸 Robby Ginepri (first round)

• # 🇩🇪 Benjamin Becker (first round)