2007 Monte Carlo Masters – Singles

Two-time defending champion Rafael Nadal defeated Roger Federer in a rematch of the previous year's final, 6–4, 6–4 to win the singles tennis title at the 2007 Monte Carlo Masters. He did not lose a single set in the entire tournament.

Seeds
The top eight seeds received a bye into the second round. • # Roger Federer (final)

• # 🇪🇸 Rafael Nadal (champion)

• # 🇷🇺 Nikolay Davydenko (second round)

• # Fernando González (second round)

• # 🇪🇸 Tommy Robredo (third round)

• # 🇷🇸 Novak Djokovic (third round)

• # Ivan Ljubičić (third round)

• # 🇬🇧 Andy Murray (withdrew because of a back injury)

• # 🇦🇷 David Nalbandian (second round, retired because of a back injury)

• # 🇨🇿 Tomáš Berdych (semifinals)

• # 🇫🇷 Richard Gasquet (quarterfinals)

• # 🇪🇸 David Ferrer (quarterfinals)

• # 🇷🇺 Mikhail Youzhny (second round)

• # 🇨🇾 Marcos Baghdatis (first round)

• # 🇫🇮 Jarkko Nieminen (first round)

• # 🇪🇸 Juan Carlos Ferrero (semifinals)