2007 Mutua Madrileña Masters Madrid – Singles

David Nalbandian defeated the defending champion Roger Federer in the final, 1–6, 6–3, 6–3 to win the singles tennis title at the 2007 Madrid Open. Nalbandian achieved the rare feat of defeating the world's top three players in the same tournament, also defeating No. 2 Rafael Nadal and No. 3 Novak Djokovic en route to the title. He joined Djokovic and Boris Becker in achieving the feat, and became the only player to defeat all of the Big Three in the same tournament.

Seeds
All seeds receive a bye into the second round. • # Roger Federer (final)

• # 🇪🇸 Rafael Nadal (quarterfinals)

• # 🇷🇸 Novak Djokovic (semifinals)

• # 🇷🇺 Nikolay Davydenko (withdrew due to an elbow injury)

• # Fernando González (quarterfinals)

• # 🇺🇸 James Blake (second round)

• # 🇪🇸 David Ferrer (second round)

• # 🇪🇸 Tommy Robredo (second round)

• # 🇨🇿 Tomáš Berdych (second round)

• # 🇫🇷 Richard Gasquet (second round)

• # 🇩🇪 Tommy Haas (second round)

• # Ivan Ljubičić (second round)

• # 🇦🇷 Guillermo Cañas (third round)

• # 🇪🇸 Carlos Moyá (second round)

• # 🇦🇷 Juan Ignacio Chela (second round)

• # 🇷🇺 Mikhail Youzhny (second round)

Qualifying seeds
• # Ernests Gulbis (first round)

• # 🇪🇸 Óscar Hernández (qualifying competition, lucky loser)

• # 🇦🇷 Agustín Calleri (qualified)

• # 🇦🇹 Stefan Koubek (qualified)

• # 🇧🇪 Kristof Vliegen (qualifying competition)

• # 🇨🇦 Frank Dancevic (qualifying competition)

• # 🇺🇸 Robby Ginepri (qualified)

• # Nicolás Massú (qualifying competition)

• # 🇫🇷 Marc Gicquel (qualified)

• # 🇺🇸 Vince Spadea (first round)

• # Andrei Pavel (qualified)

• # 🇮🇹 Simone Bolelli (qualifying competition)

Qualifiers
• # 🇫🇷 Marc Gicquel

• # 🇺🇸 Robby Ginepri

• # 🇦🇷 Agustín Calleri

• # 🇦🇹 Stefan Koubek

• # Andrei Pavel

• # 🇨🇴 Alejandro Falla

Lucky loser

 * 1) 🇪🇸 Óscar Hernández

Special exempt

 * 1)  Stanislas Wawrinka (reached the final at Vienna)