2007 Sony Ericsson Open – Men's singles

Novak Djokovic defeated Guillermo Cañas in the final, 6–3, 6–2, 6–4 to win the men's singles tennis title at the 2007 Miami Open. It was his first Masters singles title, and the first of an eventual record 40 Masters titles. He did not lose a single set in the entire tournament. At the time, Djokovic was the youngest men's singles champion in Miami Open history, until Carlos Alcaraz broke the record in 2022.

Roger Federer was the two-time defending champion, but lost in the fourth round to Cañas.

This was the last Masters tournament to feature a best of 5 sets final.

Seeds
All thirty-two seeds received a bye to the second round. • # Roger Federer (fourth round)

• # 🇪🇸 Rafael Nadal (quarterfinals)

• # 🇺🇸 Andy Roddick (quarterfinals, retired due to a hamstring injury)

• # 🇷🇺 Nikolay Davydenko (third round)

• # Fernando González (third round)

• # 🇪🇸 Tommy Robredo (quarterfinals)

• # Ivan Ljubičić (semifinals)

• # 🇺🇸 James Blake (second round)

• # 🇩🇪 Tommy Haas (second round)

• # 🇷🇸 Novak Djokovic (champion)

• # 🇦🇷 David Nalbandian (third round)

• # 🇬🇧 Andy Murray (semifinals)

• # 🇪🇸 David Ferrer (fourth round)

• # 🇨🇿 Tomáš Berdych (third round)

• # 🇫🇷 Richard Gasquet (third round)

• # 🇷🇺 Mikhail Youzhny (third round)

• # 🇨🇾 Marcos Baghdatis (second round)

• # 🇩🇪 Florian Mayer (third round)

• # 🇪🇸 Juan Carlos Ferrero (second round)

• # 🇫🇮 Jarkko Nieminen (fourth round)

• # 🇷🇺 Dmitry Tursunov (second round)

• # 🇸🇰 Dominik Hrbatý (second round)

• # 🇦🇷 Juan Ignacio Chela (quarterfinals)

• # 🇨🇿 Radek Štěpánek (fourth round)

• # 🇷🇺 Marat Safin (second round)

• # 🇦🇹 Jürgen Melzer (second round)

• # 🇪🇸 Carlos Moyá (second round)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇪🇸 Nicolás Almagro (third round)

• # 🇧🇪 Olivier Rochus (third Round, withdrew due to a foot injury)

• # 🇦🇷 José Acasuso (second round)

• # 🇫🇷 Gilles Simon (third round)