2007 U.S. Men's Clay Court Championships – Singles

Unseeded Ivo Karlović defeated Mariano Zabaleta 6–4, 6–1, to win the 2007 U.S. Men's Clay Court Championships singles event. Andy Murray entered the ATP Top 10 for the first time due to Tommy Haas failing to defend his previous year points.

Seeds
• # 🇺🇸 Andy Roddick (withdrew because of a muscle strain)

• # 🇺🇸 James Blake (semifinals)

• # 🇩🇪 Tommy Haas (quarterfinals)

• # 🇺🇸 Mardy Fish (second round)

• # 🇦🇹 Jürgen Melzer (quarterfinals)

• # 🇩🇪 Benjamin Becker (first round)

• # 🇺🇸 Robby Ginepri (first round)

• # 🇦🇷 Juan Mónaco (quarterfinals)

Key

 * Q – Qualifier
 * WC – Wildcard
 * LL – Lucky loser
 * W/O – Walkover