2007 US Open – Men's singles

Three-time defending champion Roger Federer defeated Novak Djokovic in the final, 7–6(7–4), 7–6(7–2), 6–4 to win the men's singles tennis title at the 2007 US Open. It was his fourth US Open title and 12th major title overall. With the win, Federer marked his third year in which he won three of the four majors. Also, he reached a record-equaling 14th consecutive major quarterfinal (streak starting at the 2004 Wimbledon Championships), matching Roy Emerson and Ivan Lendl. It was Djokovic's first major final appearance, and the first of an eventual record 36 major final appearances.

This was the last major appearance for former world No. 4 Tim Henman.

Seeds
• Roger Federer (champion)

• 🇪🇸 Rafael Nadal (fourth round)

• 🇷🇸 Novak Djokovic (final)

• 🇷🇺 Nikolay Davydenko (semifinals)

• 🇺🇸 Andy Roddick (quarterfinals)

• 🇺🇸 James Blake (fourth round)

• Fernando González (first round)

• 🇪🇸 Tommy Robredo (third round)

• 🇨🇿 Tomáš Berdych (fourth round, retired due to an illness)

• 🇩🇪 Tommy Haas (quarterfinals)

• 🇷🇺 Mikhail Youzhny (second round)

•  Ivan Ljubičić (third round)

• 🇫🇷 Richard Gasquet (second round, withdrew due to an illness)

• 🇦🇷 Guillermo Cañas (second round)

• 🇪🇸 David Ferrer (semifinals)

• 🇦🇺 Lleyton Hewitt (second round)

• 🇪🇸 Carlos Moyá (quarterfinals)

• 🇨🇾 Marcos Baghdatis (first round)

• 🇬🇧 Andy Murray (third round)

• 🇦🇷 Juan Ignacio Chela (quarterfinals)

• 🇪🇸 Juan Carlos Ferrero (first round)

• 🇫🇷 Paul-Henri Mathieu (first round)

• 🇦🇷 Juan Mónaco (fourth round)

• 🇦🇷 David Nalbandian (third round)

• 🇷🇺 Marat Safin (second round)

• 🇫🇮 Jarkko Nieminen (first round)

• 🇷🇺 Dmitry Tursunov (first round)

• 🇪🇸 Nicolás Almagro (third round)

• 🇮🇹 Filippo Volandri (first round)

• 🇮🇹 Potito Starace (first round)

• 🇦🇹 Jürgen Melzer (second round)

•  Ivo Karlović (first round)