2007 Western & Southern Financial Group Masters – Singles

Roger Federer defeated James Blake in the final, 6–1, 6–4 to win the men's singles tennis title at the 2007 Cincinnati Masters.

Andy Roddick was the defending champion, but lost in the third round to David Ferrer.

Seeds
The top eight seeds received a bye into the second round. • # Roger Federer (champion)

• # 🇪🇸 Rafael Nadal (second round, retired due to an arm injury)

• # 🇺🇸 Andy Roddick (third round)

• # 🇷🇸 Novak Djokovic (second round)

• # 🇷🇺 Nikolay Davydenko (semifinals)

• # Fernando González (second round)

• # 🇪🇸 Tommy Robredo (second round)

• # 🇫🇷 Richard Gasquet (second round, retired due to a blister)

• # 🇺🇸 James Blake (final)

• # 🇨🇿 Tomáš Berdych (third round)

• # Ivan Ljubičić (second round)

• # 🇩🇪 Tommy Haas (first round)

• # 🇷🇺 Mikhail Youzhny (second round)

• # 🇬🇧 Andy Murray (first round)

• # 🇦🇷 Guillermo Cañas (first round)

• # 🇪🇸 David Ferrer (quarterfinals)

Qualifying seeds
• # Ivo Karlović (withdrew)

• # 🇫🇷 Gilles Simon (first round)

• # 🇷🇺 Igor Andreev (qualifying competition)

• # 🇺🇸 Vince Spadea (qualified)

• # 🇫🇷 Julien Benneteau (qualified)

• # 🇧🇪 Olivier Rochus (qualified)

• # 🇫🇷 Michaël Llodra (first round)

• # 🇪🇸 Feliciano López (qualified)

• # 🇫🇷 Nicolas Mahut (first round)

• # 🇮🇹 Andreas Seppi (qualifying competition)

• # 🇫🇷 Sébastien Grosjean (qualifying competition, retired due to a leg injury)

• # 🇦🇷 Juan Martín del Potro (qualified)

• # 🇫🇷 Florent Serra (first round)

• # 🇺🇸 Amer Delić (qualified)

Qualifiers
• # 🇨🇴 Alejandro Falla

• # 🇦🇷 Juan Martín del Potro

• # 🇺🇸 Amer Delić

• # 🇺🇸 Vince Spadea

• # 🇫🇷 Julien Benneteau

• # 🇧🇪 Olivier Rochus

• # 🇪🇸 Feliciano López