2008 Abierto Mexicano Telcel – Men's singles

Juan Ignacio Chela was the defending champion, but lost in the second round to Agustín Calleri.

Sixth-seeded Nicolás Almagro won in the final 6–1, 7–6(7–1), against David Nalbandian.

Seeds
• # 🇦🇷 David Nalbandian (final)

• # 🇪🇸 Carlos Moyá (second round)

• # 🇦🇷 Juan Mónaco (second round)

• # 🇦🇷 Guillermo Cañas (second round)

• # 🇦🇷 Juan Ignacio Chela (second round)

• # 🇪🇸 Nicolás Almagro (champion)

• # 🇷🇺 Igor Andreev (first round)

• # 🇮🇹 Potito Starace (quarterfinals)