2008 Abierto Mexicano Telcel – Women's singles

Émilie Loit was the defending champion, but chose not to participate that year.

Flavia Pennetta won in the final 6–0, 4–6, 6–1, against Alizé Cornet.

Seeds
• # 🇮🇹 Flavia Pennetta (champion)

• # 🇫🇷 Alizé Cornet (final)

• # 🇨🇿 Klára Zakopalová (second round)

• # 🇩🇪 Martina Müller (first round)

• # 🇮🇹 Sara Errani (second round)

• # 🇦🇹 Yvonne Meusburger (second round)

• # 🇪🇪 Kaia Kanepi (semifinals)

• # 🇷🇴 Edina Gallovits (quarterfinals)

Qualifying seeds
• # 🇨🇴 Catalina Castaño (first round)

• # 🇪🇸 Nuria Llagostera Vives (withdrew)

• # 🇦🇷 Jorgelina Cravero (qualified)

• # 🇪🇸 María José Martínez Sánchez (qualified)

• # 🇪🇸 Carla Suárez Navarro (withdrew)

• # 🇨🇦 Marie-Ève Pelletier (qualifying competition)

• # 🇺🇸 Raquel Kops-Jones (qualifying competition)

• # 🇨🇴 Mariana Duque Mariño (first round)

• # 🇪🇸 Marta Marrero (qualifying competition)

• # 🇸🇰 Magdaléna Rybáriková (qualified)

Qualifiers
• # 🇪🇸 Arantxa Parra Santonja

• # 🇸🇰 Magdaléna Rybáriková

• # 🇦🇷 Jorgelina Cravero

• # 🇪🇸 María José Martínez Sánchez