2008 Copa Libertadores First Stage

The First Stage of the 2008 Copa Santander Libertadores began on January 29 and ended on February 12. Twelve teams qualified directly on this stage.

Results
Team #1 played the second leg at home.

Second leg
''Lanús and Olmedo tied 3–3 on points. Lanús advanced on goal difference.''

Cruzeiro advanced 6–0 on points.

''Mineros de Guayana and Arsenal tied 3–3 on points. Arsenal advanced on goal difference.''

''La Paz and Atlas tied 3–3 on points. Atlas advanced on goal difference.''

Cienciano advanced 4–1 on points.

''Boyacá Chicó and Audax Italiano tied 3–3 on points. Audax Italiano advanced on away goals.''