2008 Delray Beach International Tennis Championships – Singles

Xavier Malisse was the defending champion, but lost in the first round to Bobby Reynolds.

Kei Nishikori won his first ATP title at 3–6, 6–1, 6–4, against James Blake.

Seeds
• # 🇺🇸 James Blake (final)

• # 🇩🇪 Tommy Haas (first round)

• # 🇺🇸 Sam Querrey (semifinals)

• # 🇮🇱 Dudi Sela (withdrew due to personal reasons)

• # 🇩🇪 Florian Mayer (first round, retired due to a leg injury)

• # 🇺🇸 Vincent Spadea (quarterfinals)

• # 🇷🇴 Victor Hănescu (withdrew due to illness)

• # 🇺🇸 Mardy Fish (quarterfinals)