2008 Estoril Open – Men's singles

Novak Djokovic was the defending champion, but chose not to participate that year.

First-seeded Roger Federer won in the final 7–6(7–5), 1–2, after Nikolay Davydenko retired due to a left leg injury.

Seeds
• # Roger Federer (champion)

• # 🇷🇺 Nikolay Davydenko (final, retired due to a left leg injury)

• # Ivo Karlović (first round, retired due to a right knee injury)

• # 🇫🇮 Jarkko Nieminen (first round)

• # 🇫🇷 Gilles Simon (second round, retired due to a back injury)

• # 🇫🇷 Nicolas Mahut (first round)

• # 🇫🇷 Marc Gicquel (quarterfinals)

• # 🇩🇪 Michael Berrer (second round)