2008 Estoril Open – Women's singles

Gréta Arn was the defending champion, but chose not to participate that year.

Maria Kirilenko won in the final 6–4, 6–2, against Iveta Benešová.

Seeds
• # 🇮🇹 Flavia Pennetta (second round)

• # 🇷🇺 Maria Kirilenko (champion)

• # 🇮🇹 Karin Knapp (quarterfinals)

• # 🇨🇿 Lucie Šafářová (first round)

• # 🇮🇹 Tathiana Garbin (quarterfinals)

• # 🇨🇿 Klára Zakopalová (semifinals)

• # 🇸🇪 Sofia Arvidsson (second round)

• # 🇫🇷 Camille Pin (quarterfinals)