2008 Family Circle Cup – Singles

Serena Williams defeated Vera Zvonareva in the final, 6–4, 3–6, 6–3 to win the singles tennis title at the 2008 Family Circle Cup. This was Williams' third successive title in the 2008 season, and her first clay court title since the 2002 French Open.

Jelena Janković was the defending champion, but lost in the quarterfinals to Zvonareva.

Seeds
The top 8 seeds received a bye into the second round. • # 🇷🇸 Jelena Janković (quarterfinals)

• # 🇷🇺 Maria Sharapova (quarterfinals)

• # 🇷🇺 Anna Chakvetadze (second round)

• # 🇷🇺 Elena Dementieva (semifinals)

• # 🇺🇸 Serena Williams (champion)

• # 🇫🇷 Marion Bartoli (third round)

• # Patty Schnyder (quarterfinals)

• # 🇷🇺 Dinara Safina (third round)

• # 🇷🇺 Vera Zvonareva (final)

• # 🇭🇺 Ágnes Szávay (quarterfinals)

• # 🇵🇱 Agnieszka Radwańska (third round)

• # Katarina Srebotnik (third round)

• # 🇧🇾 Victoria Azarenka (third round)

• # 🇪🇸 Anabel Medina Garrigues (first round)

• # 🇸🇰 Dominika Cibulková (first round)

• # Michaëlla Krajicek (first round)

Key

 * Q = Qualifier
 * WC = Wild card
 * LL = Lucky loser
 * w/o = Walkover
 * r = Retired