2008 Fifth Third Bank Tennis Championships – Men's singles

John Isner was the defending champion, but decided not to compete this year.

Somdev Devvarman won the tournament, defeating Robert Kendrick in the final, 6–3, 6–3.

Seeds
• # 🇮🇱 Dudi Sela (semifinals)

• # 🇺🇸 Bobby Reynolds (second round)

• # 🇺🇸 Robert Kendrick (final)

• # Kristian Pless (first round)

• # 🇺🇸 Amer Delić (quarterfinals)

• # 🇮🇱 Harel Levy (first round)

• # 🇺🇸 Brendan Evans (first round)

• # 🇺🇸 Kevin Kim (first round)