2008 Fifth Third Bank Tennis Championships – Women's singles

Stéphanie Dubois was the defending champion but chose to compete at Los Angeles during the same week, reaching the second round.

16-year old Melanie Oudin won the title by defeating Carly Gullickson 6–4, 6–2 in the final.

Seeds
• # 🇬🇧 Elena Baltacha (first round)

• # 🇺🇸 Varvara Lepchenko (second round)

• # 🇯🇵 Junri Namigata (quarterfinals)

• # 🇯🇵 Kumiko Iijima (first round, retired)

• # 🇰🇷 Lee Ye-ra (semifinals)

• # 🇺🇸 Lauren Albanese (first round)

• # Chan Chin-wei (semifinals)

• # 🇺🇸 Melanie Oudin (champion)