2008 Grand Prix de Tennis de Lyon – Singles

Sébastien Grosjean was the defending champion, but lost in the first round to Robby Ginepri.

Seventh-seeded Robin Söderling won in the final 6–3, 6–7(5–7), 6–1, against Julien Benneteau.

Seeds
• # 🇺🇸 Andy Roddick (quarterfinals)

• # 🇫🇷 Richard Gasquet (second round)

• # 🇫🇷 Jo-Wilfried Tsonga (semifinals)

• # 🇫🇷 Gilles Simon (semifinals)

• # 🇪🇸 Tommy Robredo (second round)

• # Ivo Karlović (first round)

• # 🇸🇪 Robin Söderling (champion)

• # 🇫🇷 Paul-Henri Mathieu (second round)