2008 Indianapolis Tennis Championships – Singles

Dmitry Tursunov was the defending champion, but second-seeded Gilles Simon defeated him 6–4, 6–4, in the final.

Seeds
• # 🇺🇸 James Blake (semifinals)

• # 🇫🇷 Gilles Simon (champion)

• # 🇷🇺 Dmitry Tursunov (final)

• # 🇺🇸 Sam Querrey (semifinals)

• # 🇩🇪 Tommy Haas (quarterfinals)

• # 🇫🇷 Fabrice Santoro (first round)

• # 🇺🇸 Robby Ginepri (first round)

• # 🇧🇷 Thomaz Bellucci (first round)