2008 Internazionali Femminili di Palermo – Singles

Ágnes Szávay was the defending champion, but chose not to participate that year.

Sara Errani won in the final 6–2, 6–3, against Mariya Koryttseva.

Seeds
• # 🇮🇹 Flavia Pennetta (semifinals)

• # 🇪🇸 Anabel Medina Garrigues (semifinals)

• # 🇫🇷 Aravane Rezaï (first round)

• # 🇪🇸 Carla Suárez Navarro (quarterfinals)

• # 🇮🇹 Sara Errani (champion)

• # 🇧🇪 Yanina Wickmayer (first round)

• # 🇺🇦 Mariya Koryttseva (final)

• # 🇮🇹 Tathiana Garbin (quarterfinals)