2008 Italian Open – Women's singles

Defending champion Jelena Janković defeated Alizé Cornet in the final, 6–2, 6–2 to win the women's singles tennis title at the 2008 Italian Open. Cornet entered the tournament as a qualifier.

Seeds
The top eight seeds receive a bye into the second round. • # 🇷🇸 Ana Ivanovic (second round)

• # 🇷🇺 Maria Sharapova (semifinals, withdrew due to a left calf strain)

• # 🇷🇺 Svetlana Kuznetsova (third round)

• # 🇷🇸 Jelena Janković (champion)

• # 🇺🇸 Serena Williams (quarterfinals, withdrew due to a back injury)

• # 🇷🇺 Anna Chakvetadze (semifinals)

• # 🇺🇸 Venus Williams (quarterfinals)

• # 🇫🇷 Marion Bartoli (third round)

• # Patty Schnyder (quarterfinals)

• # 🇷🇺 Vera Zvonareva (third round)

• # 🇭🇺 Ágnes Szávay (second round)

• # 🇵🇱 Agnieszka Radwańska (third round)

• # 🇨🇿 Nicole Vaidišová (first round)

• # 🇷🇺 Dinara Safina (withdrew due to a low back injury)

• # 🇮🇱 Shahar Pe'er (withdrew due to a right shoulder tendinitis)

• # 🇫🇷 Amélie Mauresmo (withdrew due to right intercostal muscle strain)

• # 🇮🇹 Francesca Schiavone (second round)

• # 🇷🇺 Nadia Petrova (first round)

• # 🇦🇹 Sybille Bammer (first round)

Seeds
• # 🇫🇷 Alizé Cornet (qualified)

• # 🇷🇺 Elena Vesnina (qualified)

• # 🇫🇷 Pauline Parmentier (first round)

• # 🇨🇿 Klára Zakopalová (qualified)

• # 🇦🇺 Casey Dellacqua (first round)

• # 🇪🇪 Kaia Kanepi (qualified)

• # 🇺🇦 Mariya Koryttseva (qualified)

• # 🇷🇺 Alisa Kleybanova (qualified)

• # 🇺🇿 Akgul Amanmuradova (qualified)

• # 🇺🇸 Jill Craybas (qualified)

• # 🇨🇳 Peng Shuai (qualified)

• # 🇧🇬 Tsvetana Pironkova (qualified)

• # 🇷🇺 Anastasia Rodionova (qualifying competition, lucky loser)

• # Timea Bacsinszky (first round)

• # 🇪🇸 Virginia Ruano Pascual (qualifying competition, lucky loser)

• # 🇷🇺 Ekaterina Makarova (qualifying competition, lucky loser)

• # 🇵🇱 Marta Domachowska (first round)

• # 🇺🇦 Olga Savchuk (qualifying competition, lucky loser)

• # 🇨🇿 Iveta Benešová (qualified)

• # 🇪🇸 Nuria Llagostera Vives (Still competing in Berlin)

• # 🇷🇺 Galina Voskoboeva (qualifying competition)

• # Rossana de los Ríos (qualifying competition)

• # Chan Yung-jan (qualifying competition)

• # 🇫🇷 Émilie Loit (first round)

Qualifiers
• # 🇫🇷 Alizé Cornet

• # 🇷🇺 Elena Vesnina

• # 🇷🇴 Monica Niculescu

• # 🇨🇿 Klára Zakopalová

• # 🇨🇿 Iveta Benešová

• # 🇪🇪 Kaia Kanepi

• # 🇺🇦 Mariya Koryttseva

• # 🇷🇺 Alisa Kleybanova

• # 🇺🇿 Akgul Amanmuradova

• # 🇺🇸 Jill Craybas

• # 🇨🇳 Peng Shuai

• # 🇧🇬 Tsvetana Pironkova

Lucky losers
• # 🇷🇺 Anastasia Rodionova

• # 🇪🇸 Virginia Ruano Pascual

• # 🇷🇺 Ekaterina Makarova

• # 🇺🇦 Olga Savchuk