2008 Masters Series Monte-Carlo – Singles

Three-time defending champion Rafael Nadal defeated Roger Federer in a rematch of the previous two years' finals, 7–5, 7–5 to win the singles tennis title at the 2008 Monte-Carlo Masters. For the second year in a row, he did not lose a single set in the entire tournament.

Seeds
The top eight seeds receive a bye into the second round. • # Roger Federer (final)

• # 🇪🇸 Rafael Nadal (champion)

• # 🇷🇸 Novak Djokovic (semifinals, retired due to a sore throat)

• # 🇷🇺 Nikolay Davydenko (semifinals)

• # 🇪🇸 David Ferrer (quarterfinals)

• # 🇦🇷 David Nalbandian (quarterfinals)

• # 🇫🇷 Richard Gasquet (third round)

• # 🇷🇺 Mikhail Youzhny (second round, retired due to a neck injury)

• # 🇫🇷 Paul-Henri Mathieu (first round)

• # 🇪🇸 Carlos Moyá (first round)

• # 🇦🇷 Juan Mónaco (second round, retired due to a hand injury)

• # 🇪🇸 Tommy Robredo (third round)

• # 🇪🇸 Juan Carlos Ferrero (third round)

• # 🇬🇧 Andy Murray (third round)

• # Ivo Karlović (second round)

• # 🇩🇪 Philipp Kohlschreiber (third round)