2008 Pilot Pen Tennis – Men's singles

James Blake was the defending champion, but chose not to participate that year.

Marin Čilić won in the final 6–4, 4–6, 6–2, against Mardy Fish.

Seeds
All seeds receive a bye into the second round. • # 🇪🇸 Fernando Verdasco (semifinals)

• # Ivo Karlović (third round)

• # 🇦🇷 Juan Martín del Potro (withdrew due to fatigue)

• # 🇷🇺 Igor Andreev (quarterfinals)

• # 🇦🇷 Juan Mónaco (second round)

• # Marin Čilić (champion)

• # 🇮🇹 Andreas Seppi (quarterfinals)

• # 🇺🇸 Mardy Fish (final)

• # 🇫🇷 Marc Gicquel (third round)

• # 🇮🇹 Simone Bolelli (second round)

• # 🇦🇹 Jürgen Melzer (third round)

• # 🇦🇷 Agustín Calleri (second round)

• # 🇪🇸 Marcel Granollers (second round)

• # 🇦🇷 José Acasuso (second round)

• # 🇦🇷 Eduardo Schwank (second round)

• # 🇷🇴 Victor Hănescu (third round)