2008 Regions Morgan Keegan Championships – Singles

Tommy Haas was the defending champion, but lost in the second round to Benjamin Becker.

Steve Darcis won in the final 6–3, 7–6(7–5), against Robin Söderling.

Seeds
• # 🇺🇸 Andy Roddick (quarterfinals)

• # 🇺🇸 James Blake (withdrew due to a knee injury)

• # 🇩🇪 Tommy Haas (second round)

• # 🇨🇿 Radek Štěpánek (semifinals)

• # 🇺🇸 Sam Querrey (second round)

• # 🇸🇪 Thomas Johansson (second round)

• # 🇦🇹 Jürgen Melzer (second round)

• # 🇸🇪 Robin Söderling (final)