2008 Sony Ericsson Open – Men's singles

Nikolay Davydenko defeated Rafael Nadal in the final, 6–4, 6–2 to win the men's singles tennis title at the 2008 Miami Open. It was his second Masters title.

Novak Djokovic was the defending champion, but lost in the second round to qualifier Kevin Anderson.

Seeds
All seeds received a bye into the second round. • # Roger Federer (quarterfinals)

• # 🇪🇸 Rafael Nadal (final)

• # 🇷🇸 Novak Djokovic (second round)

• # 🇷🇺 Nikolay Davydenko (champion)

• # 🇪🇸 David Ferrer (second round)

• # 🇺🇸 Andy Roddick (semifinals)

• # 🇦🇷 David Nalbandian (second round)

• # 🇫🇷 Richard Gasquet (second round)

• # 🇺🇸 James Blake (quarterfinals)

• # 🇨🇿 Tomáš Berdych (semifinals)

• # 🇷🇺 Mikhail Youzhny (fourth round)

• # 🇫🇷 Jo-Wilfried Tsonga (third round)

• # 🇬🇧 Andy Murray (second round)

• # 🇪🇸 Tommy Robredo (second round)

• # 🇦🇷 Guillermo Cañas (fourth round)

• # 🇫🇷 Paul-Henri Mathieu (fourth round)

• # Fernando González (third round)

• # 🇦🇷 Juan Mónaco (third round)

• # Ivo Karlović (second round)

• # 🇪🇸 Carlos Moyá (third round)

• # 🇦🇺 Lleyton Hewitt (second round)

• # 🇪🇸 Juan Carlos Ferrero (third round)

• # Ivan Ljubičić (second round)

• # 🇪🇸 Nicolás Almagro (third round)

• # 🇫🇮 Jarkko Nieminen (second round)

• # 🇩🇪 Philipp Kohlschreiber (second round)

• # 🇨🇿 Radek Štěpánek (fourth round)

• # Stanislas Wawrinka (second round)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇦🇷 Juan Ignacio Chela (second round)

• # 🇷🇺 Igor Andreev (quarterfinals)

• # 🇪🇸 Feliciano López (third round)

Qualifying seeds
• # 🇧🇪 Steve Darcis (first round)

• # 🇪🇸 Guillermo García López (qualifying competition, lucky loser)

• # 🇦🇺 Chris Guccione (qualifying competition)

• # 🇩🇪 Mischa Zverev (first round)

• # Robin Haase (qualified)

• # 🇺🇸 Donald Young (qualifying competition)

• # 🇨🇿 Ivo Minář (qualified)

• # Pablo Cuevas (qualified)

• # 🇪🇨 Nicolás Lapentti (first round)

• # 🇵🇪 Luis Horna (withdrew due to an illness)

• # Nicolás Massú (first round)

• # 🇩🇪 Denis Gremelmayr (qualifying competition)

• # 🇦🇷 Juan Pablo Brzezicki (first round)

• # 🇺🇸 Bobby Reynolds (qualified)

• # 🇩🇪 Benjamin Becker (qualified)

• # 🇺🇸 Amer Delić (first round)

• # 🇷🇺 Teymuraz Gabashvili (first round)

• # 🇷🇸 Viktor Troicki (qualified)

• # Lu Yen-hsun (qualified)

• # Paul Capdeville (qualifying competition)

• # 🇺🇸 Robert Kendrick (first round)

• # 🇷🇺 Igor Kunitsyn (qualified)

• # Kevin Anderson (champion)

• # 🇺🇸 Wayne Odesnik (qualifying competition)

Qualifiers
• # Kevin Anderson

• # 🇩🇪 Benjamin Becker

• # 🇺🇸 Sam Warburg

• # 🇨🇴 Santiago Giraldo

• # Robin Haase

• # 🇺🇸 Bobby Reynolds

• # 🇨🇿 Ivo Minář

• # Pablo Cuevas

• # Lu Yen-hsun

• # 🇷🇸 Viktor Troicki

• # 🇺🇸 Ryan Sweeting

• # 🇷🇺 Igor Kunitsyn

Lucky loser

 * 1) 🇪🇸 Guillermo García López