2008 US Open – Girls' singles

Kristína Kučová was the defending champion, but did not compete in the juniors that year.

CoCo Vandeweghe won the tournament, defeating Gabriela Paz in the final, 7–6(7–3), 6–1.

Seeds
• # Arantxa Rus (first round)

• # 🇺🇸 Melanie Oudin (semifinals)

• # 🇹🇭 Noppawan Lertcheewakarn (third round)

• # 🇦🇺 Jessica Moore (withdrew)

• # 🇷🇴 Elena Bogdan (quarterfinals)

• # 🇷🇴 Ana Bogdan (first round)

• # 🇯🇵 Kurumi Nara (third round)

• # 🇷🇺 Ksenia Lykina (second round)

• # Jessy Rompies (first round)

• # 🇫🇷 Cindy Chala (first round)

• # 🇧🇪 Tamaryn Hendler (quarterfinals)

• # 🇫🇷 Kristina Mladenovic (semifinals)

• # 🇷🇺 Elena Chernyakova (first round)

• # 🇦🇺 Johanna Konta (first round)

• # 🇩🇪 Linda Berlinecke (first round)

• # 🇯🇵 Aki Yamasoto (first round)