2008 US Open – Mixed doubles

Victoria Azarenka and Max Mirnyi were the defending champions, but Azarenka chose not to participate. Mirnyi partnered with Anna Chakvetadze, but lost in the first round to Nadia Petrova and Jonas Björkman.

Cara Black and Leander Paes won the title, defeating Liezel Huber and Jamie Murray in the final 7–6(8–6), 6–4.

Seeds
• # Chia-jung Chuang / 🇨🇦 Daniel Nestor (first round)

• # Katarina Srebotnik / 🇷🇸 Nenad Zimonjić (quarterfinals)

• # 🇯🇵 Ai Sugiyama / Kevin Ullyett (first round)

• # Yung-jan Chan / 🇦🇹 Julian Knowle (first round)

• # Cara Black / 🇮🇳 Leander Paes (champions)

• # 🇨🇿 Květa Peschke / 🇨🇿 Pavel Vízner (second round)

• # 🇨🇳 Yan Zi / Mark Knowles (first round)

• # 🇫🇷 Nathalie Dechy / 🇮🇱 Andy Ram (first round)