2008 Zurich Open – Singles

Justine Henin was the defending champion, but retired from the sport on May 14, 2008.

Venus Williams won in the final 7–6(7–1), 6–2, against Flavia Pennetta.

Seeds
The top four seeds receive a bye into the second round. • # 🇷🇸 Jelena Janković (second round)

• # 🇷🇸 Ana Ivanovic (semifinals)

• # 🇺🇸 Venus Williams (champion)

• # 🇷🇺 Vera Zvonareva (second round, retired due to dizziness)

• # 🇵🇱 Agnieszka Radwańska (second round)

• # Patty Schnyder (first round)

• # 🇷🇺 Anna Chakvetadze (first round)

• # 🇸🇰 Daniela Hantuchová (first round)