2009 Abierto Mexicano Telcel – Women's singles

Flavia Pennetta was the defending champion, but lost in the final to Venus Williams, 6–1, 6–2.

Seeds
• # 🇺🇸 Venus Williams (champion)

• # 🇮🇹 Flavia Pennetta (final)

• # 🇪🇸 Carla Suárez Navarro (second round)

• # 🇨🇿 Iveta Benešová (semifinals)

• # 🇦🇷 Gisela Dulko (second round)

• # 🇨🇿 Lucie Šafářová (first round)

• # 🇮🇹 Tathiana Garbin (second round, retired due to abdominal strain)

• # 🇪🇸 María José Martínez Sánchez (second round)