2010–11 Maltese Second and Third Division Knock-Out

The 2010–11 Second and Third Division Knock-Out (known as quick Keno Second and Third Division Knock-Out for sponsorship reasons) was a knockout tournament for Maltese football clubs playing in the Second and Third Division. Played between 1 September 2010 and 8 May 2011, Żejtun Corinthians successfully defended last season's title.