2010 AMA Pro American Superbike Championship

The 2010 AMA Pro American Superbike Championship was the 35th running of the AMA Superbike Championship, an American motorcycle racing championship. Title sponsors for the series include Sunoco, Amsoil, National Guard, Dunlop, Speedcom and SunTrust.

Josh Hayes won his first championship, becoming the first champion riding a Yamaha since 1991.