2010 Abierto Mexicano Telcel – Men's singles

Nicolás Almagro was the defending champion; however, he lost 1–6, 7–5, 2–6 to Juan Carlos Ferrero in the quarterfinals. David Ferrer won in the final 6–3, 3–6, 6–1 against Juan Carlos Ferrero.

Seeds
• # 🇪🇸 Fernando Verdasco (quarterfinals)

• # Fernando González (semifinals)

• # 🇪🇸 David Ferrer (champion)

• # 🇪🇸 Juan Carlos Ferrero (final)

• # 🇺🇸 John Isner (first round)

• # 🇪🇸 Nicolás Almagro (quarterfinals)

• # 🇦🇷 Juan Mónaco (semifinals, retired due to an abdominal strain)

• # 🇪🇸 Albert Montañés (second round)

Seeds
• # 🇦🇷 Eduardo Schwank (qualified)

• # Nicolás Massú (qualifying competition)

• # 🇷🇴 Victor Crivoi (qualified)

• # 🇮🇱 Harel Levy (qualifying competition)

• # 🇪🇸 Alberto Martín (qualified)

• # 🇦🇷 Gastón Gaudio (first round)

• # 🇦🇷 Sebastián Decoud (qualifying competition)

• # 🇦🇷 Diego Junqueira (qualified)

Qualifiers
• # 🇦🇷 Eduardo Schwank

• # 🇦🇷 Diego Junqueira

• # 🇷🇴 Victor Crivoi

• # 🇪🇸 Alberto Martín