2010 Abierto Mexicano Telcel – Women's singles

Venus Williams was the defending champion, and she won in the final 2–6, 6–2, 6–3 against Polona Hercog.

Seeds
• # 🇺🇸 Venus Williams (champion)

• # 🇭🇺 Ágnes Szávay (quarterfinals, retired due to a left abdominal strain)

• # 🇦🇷 Gisela Dulko (quarterfinals)

• # 🇷🇴 Sorana Cîrstea (first round)

• # 🇪🇸 Carla Suárez Navarro (semifinals)

• # 🇮🇹 Sara Errani (second round)

• # 🇮🇹 Roberta Vinci (second round)

• # Polona Hercog (final)