2010 Andalucia Tennis Experience – Singles

Jelena Janković was the defending champion, but chose not to participate that year.

Flavia Pennetta defeated Carla Suárez Navarro 6–2, 4–6, 6–3 to win the 2010 title.

This is notable for being the first main draw appearance of future world No. 1 and Grand Slam champion Simona Halep where she lost in the quarterfinals to Flavia Pennetta.

Seeds
• # 🇧🇾 Victoria Azarenka (quarterfinals, retired due to a left thigh injury)

• # 🇮🇹 Flavia Pennetta (champion)

• # 🇧🇪 Kim Clijsters (second round)

• # 🇫🇷 Aravane Rezaï (second round)

• # 🇪🇸 María José Martínez Sánchez (semifinals)

• # 🇷🇺 Maria Kirilenko (first round)

• # 🇪🇸 Anabel Medina Garrigues (second round)

• # 🇪🇸 Carla Suárez Navarro (final)