2010 Arizona Wildcats softball team

The 2010 Arizona Wildcats softball team represented the University of Arizona in the 2010 NCAA Division I softball season. The Wildcats were coached by Mike Candrea, who led his twenty-third season. The Wildcats finished with a record of 52–14. They competed in the Pacific-10 Conference, where they finished third with a 12–8 record.

The Wildcats were invited to the 2010 NCAA Division I softball tournament, where they swept the Regional and then completed a run to the title game of the Women's College World Series where they fell to champion UCLA.