2010 Australian Open – Wheelchair women's singles

Korie Homan defeated Florence Gravellier in the final, 6–2, 6–2 to win the women's singles wheelchair tennis title at the 2010 Australian Open.

Esther Vergeer was the four-time reigning champion, but did not participate this year.

Seeds

 * 1) Korie Homan (champion)
 * 2) 🇫🇷 Florence Gravellier (final)