2010 Bancolombia Open – Singles

Horacio Zeballos was the defender of championship title, however he chose to participate at Houston. João Souza won in the final 4–6, 6–4, 6–1 against Alejandro Falla.

Seeds
• # 🇨🇴 Alejandro Falla (final)

• # 🇨🇴 Santiago Giraldo (semifinals)

• # 🇮🇹 Paolo Lorenzi (quarterfinals)

• # 🇪🇨 Nicolás Lapentti (second round)

• # 🇧🇷 Ricardo Mello (semifinals)

• # 🇧🇷 Thiago Alves (first round)

• # 🇺🇸 Kevin Kim (first round)

• # 🇧🇷 João Souza (champion)