2010 Brisbane International – Men's singles

Radek Štěpánek was the defending champion, but he lost in the final to Andy Roddick, 7–6(7–2), 7–6(9–7).

Seeds
• # 🇺🇸 Andy Roddick (champion)

• # 🇨🇿 Radek Štěpánek (final)

• # 🇫🇷 Gaël Monfils (semifinals)

• # 🇨🇿 Tomáš Berdych (semifinals)

• # 🇺🇸 Sam Querrey (first round)

• # 🇦🇹 Jürgen Melzer (first round)

• # 🇫🇷 Jérémy Chardy (first round)

• # 🇧🇷 Thomaz Bellucci (quarterfinals)

Qualifying
The top six seeds received byes into the second round.

Seeds
• # 🇧🇪 Xavier Malisse (qualifying competition)

• # 🇺🇦 Alexandr Dolgopolov (qualified)

• # 🇩🇪 Julian Reister (qualified)

• # 🇦🇺 Marinko Matosevic (qualifying competition)

• # 🇬🇧 Brydan Klein (second round)

• # 🇮🇹 Andrea Stoppini (second round)

• # 🇦🇺 Greg Jones (second round)

• # 🇦🇺 Nick Lindahl (qualified)

Qualifiers
• # 🇦🇺 Nick Lindahl

• # 🇺🇦 Alexandr Dolgopolov

• # 🇩🇪 Julian Reister

• # 🇦🇺 Matthew Ebden