2010 CSU Pueblo ThunderWolves football team

The 2010 CSU Pueblo ThunderWolves football team represented Colorado State University–Pueblo as a member of the Rocky Mountain Athletic Conference (RMAC) during 2010 NCAA Division II football season. Led by third-year head coach John Wristen, the ThunderWolves compiled an overall record of 9–2 with a mark of 7–2 in conference play, tying for third place in the RMAC. CSU Pueblo played their home games at Neta and Eddie DeRose ThunderBowl in Pueblo, Colorado.