2010 Copa BBVA-Colsanitas – Singles

María José Martínez Sánchez was the defending champion, but chose to compete in the 2010 Dubai Tennis Championships instead. Mariana Duque Mariño won in the final 6–4, 6–3, against Angelique Kerber.

Seeds
• # 🇦🇷 Gisela Dulko (semifinals)

• # 🇪🇸 Carla Suárez Navarro (first round)

• # 🇮🇹 Sara Errani (quarterfinals)

• # Polona Hercog (first round)

• # 🇩🇪 Angelique Kerber (final)

• # 🇨🇿 Sandra Záhlavová (quarterfinals)

• # 🇨🇿 Klára Zakopalová (quarterfinals)

• # 🇪🇸 Arantxa Parra Santonja (semifinals)