2010 Copa Petrobras Asunción – Singles

Ramón Delgado was the defending champion. This year he reached the final, losing, however, to 7th seed Rui Machado 2–6, 6–3, 5–7.

Seeds
• # 🇮🇹 Fabio Fognini (second round)

• # 🇪🇸 Pere Riba (quarterfinals)

• # 🇪🇸 Rubén Ramírez Hidalgo (quarterfinals)

• # 🇦🇷 Brian Dabul (second round)

• # 🇦🇷 Carlos Berlocq (semifinals)

• # 🇪🇸 Albert Ramos-Viñolas (second round)

• # Rui Machado (champion)

• # Nicolás Massú (second round)