2010 Copa Petrobras Santiago – Singles

Eduardo Schwank was the defending champion but decided not to participate.

Fabio Fognini defeated Paul Capdeville 6–2, 7–6(2) in the final.

Seeds
• # 🇮🇹 Fabio Fognini (champion)

• # 🇪🇸 Pere Riba (first round)

• # 🇪🇸 Rubén Ramírez Hidalgo (second round)

• # 🇧🇷 João Souza (quarterfinals)

• # 🇪🇸 Albert Ramos Viñolas (second round)

• # Rui Machado (semifinals)

• # 🇰🇿 Yuri Schukin (first round)

• # Nicolás Massú (first round, retired)